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PATHOGENICITY OF
MALARIA PARASITE
ABSTRACT
The prevalence of malaria is becoming polarized. This work
first deals with the malaria‐causing parasite, Plasmodium falciparum, its
epidemiology, and the clinical manifestation and disease pathogenesis.
Susceptibility to severe malaria manifestations varies across individuals, with
underlying host immunity as a major determinant of susceptibility.
Malaria‐infected hosts can generate a wide range of immune responses to malaria
parasites and/or parasite antigens. Host antibody response is one of the most important
components of protective immunity in malaria. The work then discusses other
parasites P. vivax, P. malariae, P. ovale, and P. knowlesi. Accurate diagnosis
of malaria is essential, particularly in areas where there is resistance to
control measures. The work also discusses treatment, prevention and control of
malaria, and ends with a note on the re‐emergence of malaria.
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